/* /content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/css/duality.css */

#il33-duality #body-wrapper p,
#il33-duality #body-wrapper h1,
#il33-duality #body-wrapper h2,
#il33-duality #body-wrapper h3,
#il33-duality #body-wrapper h4,
#il33-duality #body-wrapper h5,
#il33-duality #body-wrapper a,
#il33-duality #body-wrapper li,
#il33-duality .tooltip-content {
  font-family: "Barlow", sans-serif;
}


#il33-duality #body-wrapper .cmp-text {
  padding: 0;
}
#il33-duality #right-item-information .cmp-youtubevideo__playicon::before {
  display: none;
}

#il33-duality #body-wrapper {
  margin-top: 84px;
  padding: 0;
  position: relative;
}

#il33-duality #body-wrapper::before {
  content: "";
  position: absolute;
  inset: 0;
  background-color: #fafafa;
  z-index: -2;
}

#il33-duality #title-section,
#il33-duality #reduced-il-section {
  padding: 0 15px;
}

#il33-duality #purple-background {
  background: linear-gradient(180deg, #f1e7ef 0%, #fafafa 100%);
}

#il33-duality #title-section {
  padding: 45px 15px 34px;
}

#il33-duality #title-section .eyebrown-text {  text-align: left;}
#il33-duality .eyebrown-text {
  font-weight: 600;
  font-size: 18px;
  line-height: 150%;
  text-transform: uppercase;
  color: #46163f;
  text-align: center;
}

#il33-duality h1 {
  font-weight: 700;
  font-size: 34px;
  line-height: 38px;
  text-transform: uppercase;
  color: #79266a;
  margin: 5px 0 0px;
}

#il33-duality #title-section h2 {
  font-weight: 600;
  font-size: 18px;
  line-height: 150%;
  color: #222222;
}

#il33-duality #images-container {
  display: flex;
  justify-content: center;
  align-items: center;
  flex-wrap: wrap;
  gap: 20px;
  margin-bottom: 20px;
}

#il33-duality #reduced-il-section h2 {
  font-weight: 700;
  font-size: 28px;
  line-height: 150%;
  text-transform: uppercase;
}

#il33-duality #reduced-il-section #orange-title {
  color: #d34600;
}

#il33-duality #reduced-il-section #green-title {
  color: #5f6d10;
}

#il33-duality #images-container img {
  width: 110px;
}

#il33-duality #images-container .image {
  flex: 0 0 31%;
}

#il33-duality #images-container .title {
  flex: 0 0 63%;
}

#il33-duality h2{
  font-weight:700;
  font-size:32px;
  line-height:150%;
  text-align:center;
  margin: 0 15px 20px;
  color: #79266A;
}

#il33-duality .arrow-box {
  display: inline-block;
  padding: 12px 31px 35px;
  max-width: 360px;
  width: 100%;
  margin: 0 auto;
  font-weight: 700;
  font-size: 20px;
  line-height: 100%;
  text-align: center;
  color: #46163f;
  background: linear-gradient(
    180deg,
    rgba(205, 200, 205, 0) 15.77%,
    #cdc8cd 100%
  );
  clip-path: polygon(0 0, 100% 0, 100% 70%, 50% 100%, 0 70%);
  border-radius: 6px;
}

#il33-duality .no-bold {
  font-weight: 400;
}

#il33-duality #body-wrapper .imagelist ul li{
  font-weight: unset;
  font-size: unset;
  line-height: unset;
  color: unset;
  position: unset;
  padding: unset;
}

#il33-duality #body-wrapper .imagelist ul li::after{
  display:none;
}

#il33-duality #body-wrapper ul {
  margin: 0;
  list-style: none;
}

#il33-duality #body-wrapper ul li {
  font-weight: 400;
  font-size: 18px;
  line-height: 150%;
  color: #222222;
  position: relative;
  padding: 0 0 5px 12px;
}

#il33-duality #body-wrapper ul li::after {
  content: "\2022";
  position: absolute;
  left: 0px;
  top: 0px;
  font-size: 18px;
  color: #79266A;
}

#il33-duality #body-wrapper .orange-bullets li::after {
  color: #d34600;
}

#il33-duality #body-wrapper .green-bullets li::after {
  color: #5f6d10;
}

#il33-duality #li-container {
  margin-bottom: 25px;
}

#il33-duality #middle-item {
  margin-bottom: 30px;
  display: flex;
  justify-content: center;
}

#il33-duality #purple-container {
  max-width: 100%;
  margin: 30px 15px 65px;
  border-top: 2px solid #79266a;
  border-bottom: 2px solid #79266a;
  padding: 20px 15px;
  display: flex;
  justify-content: center;
  align-items: center;
  position: relative;
}

#il33-duality #purple-container h2 {
  font-weight: 700;
  font-size: 20px;
  line-height: 110%;
  text-align: center;
  text-transform: uppercase;
  color: #79266a;
}

#il33-duality #purple-container::after {
  content: "";
  width: 23px;
  height: 50px;
  position: absolute;
  left: 48.1%;
  bottom: -50px;
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/arrow.svg);
  background-size: contain;
  background-repeat: no-repeat;
}

#il33-duality #dysregulation-container, #il33-duality #ed-container {
  border: 1px solid #79266a;
  border-radius: 10px;
  padding: 25px 19px;
  margin: 0 15px;
  position: relative;
}

#il33-duality #dysregulation-container{
  padding: 30px 19px 25px 19px ;
}

#il33-duality #ed-container{
  padding:40px 12px 40px 12px ;
}


#il33-duality #ed-container #colourArrows #greenArrow{
  position:relative;
  margin-left: 63px;
}


#il33-duality #down-arrow{
  max-width:22px;
  margin:0 auto;
}

#il33-duality #dysregulation-container::after {
  content: "";
  position: absolute;
  top: 0;
  left: 0;
  border-radius: 10px;
  background-color: #fff;
  height: 100%;
  width: 100%;
  z-index: -2;
}

#il33-duality #dysregulation-container p.dysregulation-title, #il33-duality #ed-container p.dysregulation-title {
  font-weight: 400;
  font-size: 25px;
  line-height: 150%;
  letter-spacing: 0%;
  text-align: center;
  color: #222222;
  margin-bottom:20px;
}

#il33-duality #dysregulation-container p.dysregulation-title{
    font-size: 24px;
    line-height: normal;
}

#il33-duality #ed-container p.dysregulation-title {
    margin-bottom:0;
    padding: 0 5px;
    font-size: 24px;
    max-width: 96%;
    margin: 0 auto;
}

#il33-duality #ed-container .mod-dl{
  font-size:24px;
  line-height:150%;
  margin: 62px 0 20px;
}

#il33-duality #ed-container .mod-dl img{
  margin-left:5px;
}

#il33-duality #ed-container .mod-dl .dl-link{
  color:#46163F;
  font-weight:700;
  text-decoration: underline;
}

#il33-duality #ed-container .mod-dl .dl-link:hover{
  text-decoration: none;
}

#il33-duality #dysregulation-container p.dysregulation-title.btm-0 {
  margin-bottom:0px;
}
#il33-duality #txt-associate{margin:11px 30px 0;    }

#il33-duality #txt-associate .two-fold-text {
  padding-bottom: 30px;
    
}
#il33-duality .two-fold-text{
  font-size:28px;
  margin:0 15px;
  text-align:center;
  line-height:150%;
  color:#79266A;
  font-weight:700;
  border-bottom: 1px solid #9C919A;
  padding-bottom: 40px;
}

#il33-duality .dysregulation-text {
  font-weight: 400;
  font-size: 20px;
  line-height: 150%;
  text-align: center;
  margin-top: 3px;
  color: #222222;
}

/* image list */

#il33-duality #downstream-cell-types,#il33-duality #inflammation-cell-types{
    display: flex;
    align-items: flex-start;
    justify-content: center;
    gap: 47px;
}

#il33-duality #downstream-cell-types .image #middle-arrow1{
    height:210px;
}
#il33-duality #downstream-cell-types .imagelist{
 margin-top:18px;   
}

#il33-duality #downstream-cell-types .cmp-imagelist, #il33-duality #inflammation-cell-types .cmp-imagelist{
    display: flex;
    gap: 13px;
    align-items: center;
    flex-direction: column;
    justify-content: center;
}
#il33-duality #inflammation-cell-types .cmp-imagelist{
    gap: 8px;
 }
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item, #il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item{
    display:flex;
    flex-direction:column;
    align-items:center;
    justify-content:center;
    gap:3px;
}
 #il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item{
    gap:4px;
 }

#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.mast-cells img{ width:29px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.ILC2s img{ width:33px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Eosinophils img{width:29px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Neutrophils img{width:29px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Macrophages img{width:41px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Tcells img{width:36px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-4 img{width:38px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-5 img{width:23px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-13 img{width:31px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IFN-y img{width:35px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.TNF-a img{width:37px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-13 {margin-top:5px}

#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item p, #il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item p{
    font-family: "Barlow Semi Condensed", sans-serif;
   font-weight:500;
  font-size:12px;
  line-height:100%;
}

/* image list ends */

#dysregulation-container #first-arrow{
  max-width:22px;
  margin:0 auto;
  margin-bottom:7px;
}

#dysregulation-container #waste{
  max-width:75px;
  margin:0 auto;
  margin-bottom:10px;
  padding-right:8px;
}

#dysregulation-container .inbtw-text{
  font-size: 15px;
  font-weight:700;
  text-align:center;
}

#dysregulation-container .inbtw-text.second-time{
    padding: 12px 0 14px;
    font-size:14px;
}
#dysregulation-container .inbtw-text.second-time .text-1{
    padding-bottom:2px;
}

#dysregulation-container .first-time.inbtw-text .text-1{
    padding-bottom: 1px;
}
#dysregulation-container .inbtw-text .text-1{
  color:#47163F;
  padding-bottom:6px;
}

#dysregulation-container .inbtw-text .text-2{
  color:#831D6D;
  padding-bottom:6px;
  margin: 0 auto;
  max-width: 95%;
}

#inflammation-cell-types .right-list-txt, #inflammation-cell-types .left-list-txt{
  font-weight:700;
  font-size:14px;
  line-height:100%;
  color:#3C0937;
  padding-bottom:11px;
  text-align: center;
}


#il33-duality #duality-section {
  display:flex;
}

#il33-duality #duality-section #duality-box1, #il33-duality #duality-section #duality-box-2{
  display:flex;
  flex-direction:column;
  border:0.75px solid;
  border-radius:5px;
  padding:11px 1.4px 28px;
  align-items:center;
  justify-content:center;
  gap: 7px;
  max-width: 427px;
  position: relative;
}


#il33-duality #duality-section #duality-box1{
  border-color:#D34600;width: 126px;
}
#il33-duality #duality-section #duality-box1 .image{ width:42px;}

#il33-duality #duality-section #duality-box-2{
  border-color:#5F6D10;width: 126px;
  padding-bottom:12px;
}

#il33-duality #duality-section #duality-box-2 .image{ width:42px;}

#il33-duality #duality-section .inside-box .text-1{
  font-size:14px;
  text-align:center;
  font-weight:700;
  line-height:100%;
  padding-bottom:3.5px;
}

#il33-duality #duality-section .inside-box .text-2{
    font-family: "Barlow Semi Condensed", sans-serif;
    font-size: 10px;
    text-align:center;
    font-weight:400;
    line-height: normal;
    margin-top:4px;
    padding: 0 3px;
}

#il33-duality #duality-section #grey-container{
  width: 62px;
  margin-left: 4px;
  margin-top:82px;
}

#il33-duality #duality-section .inside-box.red .text-1{
  color:#D34600;    padding: 0px 5px;
}
#il33-duality #duality-section .inside-box.green .text-1{
  color:#5F6D10;    padding: 0px 5px;
}

#il33-duality #duality-section #red-shadow,#il33-duality #duality-section #green-shadow{
  margin:0 auto;
  max-width: 126px;
}

#il33-duality #duality-section #red-shadow{
    padding-top: 13px;
    /*background: linear-gradient(180deg, hsl(19.91deg 100% 41.37% / 7%) 3%, hsl(19.91deg 100% 41.37% / 7%) 42%, rgba(211, 70, 0, 0) 100%);*/
    /*background-position-y: top -30px;*/
    /*background-repeat: no-repeat;*/
}
#il33-duality #duality-section #green-shadow{
    padding-top: 13px;
/*    background: linear-gradient(180deg, rgb(180 189 70 / 7%) 3%, rgb(180 189 70 / 7%) 42%, rgba(180, 189, 70, 0) 100%);*/
/*background-position-y: top -30px;*/
/*    background-repeat: no-repeat;*/
}

#il33-duality #duality-section #red-shadow .image{width:43px;margin: auto;}
#il33-duality #duality-section #green-shadow .image{width:40px;margin: auto;}
#il33-duality #duality-section #red-shadow #txt-red-shadow,#il33-duality #duality-section #green-shadow #txt-green-shadow {margin-top:7px}
#il33-duality #duality-section #red-shadow #txt-red-shadow .shade-text,
#il33-duality #duality-section #green-shadow #txt-green-shadow .shade-text{
    font-family: "Barlow Semi Condensed", sans-serif;
    font-size: 10px;
    text-align: center;
    font-weight: 400;
    line-height: 100%;
    color:#221F20;
    padding: 0 6px;
}

#il33-duality #duality-section #green-shadow #txt-green-shadow .shade-text{
    padding: 0 14px;
    
}
#il33-duality #duality-section #red-shadow #txt-red-shadow .shade-text.red span{
    font-weight: 700;
    color:#D34600;
}
#il33-duality #duality-section #green-shadow #txt-green-shadow .shade-text.green span{
    font-weight: 700;
    color:#5F6D10;
}

#il33-duality #key-role-section{
  margin: 40px 15px 60px;
}


#il33-duality #key-role-section #responsive-flex{
  display:flex;
  flex-direction:column;
}

#il33-duality #key-role-section #responsive-flex #flex-left,#il33-duality #key-role-section #responsive-flex #flex-right{
  display:flex;
  flex-direction:column;
  justify-content:center;
  align-items: center;
  gap:30px;
}


#il33-duality #key-role-section .key-role-copd{
  font-size:24px;
  font-weight:700;
  line-height:150%;
  margin-bottom: 60px;
}

#il33-duality #key-role-section .key-role-flex{
    display: flex;
    flex-direction: column;
}

#il33-duality #key-role-section .key-role-left, #il33-duality #key-role-section .key-role-right{
    display: flex;
    flex-direction: column;
    justify-content: center;
    align-items: center;
    gap: 30px;
}

#il33-duality #key-role-section .key-role-left{
  padding-bottom:30px;
  border-bottom:1px solid #9C919A;
}

#il33-duality #key-role-section #flex-right img{
  padding-top:30px;
}

#il33-duality .dysregulation-image-title {
  font-weight: 600;
  font-size: 14px;
  line-height: 150%;
  text-align: center;
  margin: 15px 0 5px;
}

#il33-duality #airway-epithelial-damage-image {
  margin: 0 auto;
}

#il33-duality .tooltip-wrapper {
  position: relative;
  display: inline-flex;
  align-items: center;
  cursor: pointer;
}

#il33-duality .tooltip-toggle {
  position: absolute;
  opacity: 0;
  pointer-events: none;
}

#il33-duality .tooltip {
  display: none;
  bottom: -54px;
  left: 57%;
  transform: translateX(-50%) scale(0.95);
  width: 150px;
  background: #fff;
  border: 1px solid #9b7f8f;
  border-radius: 6px;
  padding: 6px;
  box-shadow: 0 6px 18px rgba(0, 0, 0, 0.15);
  opacity: 0;
  pointer-events: none;
  transition: 0.25s ease;
  z-index: 999;
}

#il33-duality .tooltip::before {
  content: "";
  position: absolute;
  top: -5px;
  left: 66.7%;
  transform: translateX(-50%) rotate(45deg);
  width: 8px;
  height: 8px;
  background: white;
  border-left: 1px solid #9b7f8f;
  border-top: 1px solid #9b7f8f;
}

#il33-duality .tooltip-toggle:checked ~ .tooltip {
  opacity: 1;
  transform: translateX(-50%) scale(1);
  pointer-events: auto;
}

#il33-duality .tooltip-close {
  position: absolute;
  top: 10px;
  right: 12px;
  cursor: pointer;
  display: flex;
  align-items: center;
  justify-content: center;
}

#il33-duality .right-arrow .tooltip-close img {
  }

#il33-duality .tooltip-close::after {
  content: "";
  position: absolute;
  inset: -10px;
}

#il33-duality .tooltip-close:active,
#il33-duality .tooltip-close:hover {
  color: #000;
}

#il33-duality .tooltip-close {
  display: block;
}

#il33-duality .tooltip-close {
  pointer-events: auto;
  display: inline-block;
  user-select: none;
  pointer-events: auto;
  display: inline-block;
  cursor: pointer;
  position: absolute;
  right: 2px;
  top: 2px;
}

#il33-duality .tooltip-content {
  font-size: 9px;
  line-height: 4px;
}

#il33-duality #reduced-accordion .cmp-accordion__button,
#il33-duality #reduced-accordion .cmp-accordion__icon {
  padding: 0;
}

#il33-duality #reduced-accordion {
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  align-content: flex-start;
  row-gap: 0;
}

#il33-duality #reduced-accordion .cmp-accordion__item {
  display: contents;
}

#il33-duality #reduced-accordion .cmp-accordion__header {
  flex: 0 0 109px;
  width: 109px;
}

#il33-duality #reduced-accordion .cmp-accordion__header:has(.right-arrow) {
  flex: 0 0 101px;
  width: 101px;
}

#il33-duality #reduced-accordion .cmp-accordion__panel {
  flex: 0 0 100%;
  width: 100%;
  max-width: 100%;
  order: 10;
  flex-basis: 100%;
}

#il33-duality #reduced-accordion .cmp-accordion__item:empty {
  display: none;
}

#il33-duality
  #reduced-accordion
  .cmp-accordion__item:not(:has(.cmp-accordion__header)) {
  display: none;
}

#il33-duality #reduced-accordion .flex-items {
  display: flex;
  justify-content: center;
  align-items: center;
  flex-direction: column;
  gap: 5px;
}

#il33-duality #reduced-accordion .flex-items img {
  width: 18.85px;
}

#il33-duality #reduced-accordion .accordion-title {
  font-weight: 700;
  font-size: 14px;
  line-height: normal;
}

#il33-duality #reduced-accordion .orange-section .accordion-title,
#il33-duality #reduced-accordion .orange-section .accordion-subtitle {
  color: #d34600;
}

#il33-duality #reduced-accordion .green-section .accordion-title,
#il33-duality #reduced-accordion .green-section .accordion-subtitle {
  color: #5f6d10;
}

#il33-duality #reduced-accordion .accordion-subtitle {
  font-weight: 700;
  font-size: 12px;
  line-height: 13px;
  text-align: center;
  padding: 2px 5px 0;
}

#il33-duality #reduced-accordion .cmp-accordion__button {
  padding: 8px 4px 20px;
}

#il33-duality #reduced-accordion .cmp-accordion__button:has(.orange-section) {
  border: 1px solid #d34600;
  background-color: #fffdfc;
}

#il33-duality
  #reduced-accordion
  .cmp-accordion__button.cmp-accordion__button--expanded:has(.orange-section) {
  border: 2px solid #d34600;
}

#il33-duality #reduced-accordion .cmp-accordion__button:has(.green-section) {
  border: 1px solid #5f6d10;
  background-color: #f7f8f3;
}

#il33-duality
  #reduced-accordion
  .cmp-accordion__button.cmp-accordion__button--expanded:has(.green-section) {
  border: 2px solid #5f6d10;
}
#il33-duality #reduced-accordion .cmp-accordion__icon {
  z-index: 2;
}
#il33-duality #reduced-accordion .cmp-accordion__icon {
  position: absolute;
  left: 37%;
  bottom: 13px;
}

#il33-duality #reduced-accordion .cmp-accordion__icon::before {
  content: "";
  position: absolute;
  width: 28px;
  height: 28px;
  background-size: contain;
  background-repeat: no-repeat;
}
#il33-duality
  #reduced-accordion
  > div:nth-child(1)
  .cmp-accordion__button.cmp-accordion__button--expanded
  .cmp-accordion__icon::before {
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/minus-image-orange.svg);
}

#il33-duality
  #reduced-accordion
  > div:nth-child(1)
  .cmp-accordion__icon::before {
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/plus-image-orange.svg);
}

#il33-duality
  #reduced-accordion
  > div:nth-child(3)
  .cmp-accordion__icon::before {
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/plus-image-green.svg);
}

#il33-duality
  #reduced-accordion
  > div:nth-child(3)
  .cmp-accordion__button.cmp-accordion__button--expanded
  .cmp-accordion__icon::before {
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/minus-image-green.svg);
}

#il33-duality #reduced-accordion > div:nth-child(2) {
  cursor: none;
  pointer-events: none;
}

#il33-duality #airway-epithelial-damage-image {
  max-width: 322px;
}


#il33-duality #ed-container #colourArrows #txt-arrow-container{
    width: 100%;
}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container{height:84px;display: flex;width: 100%;}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-left-arrow{
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/mobile/il33-duality/redArrow-mobile.svg);
    background-size: auto;
    height: 100%;
    width: 71px;
    background-repeat: no-repeat;
    left: 0;
    margin-left: 55px;
}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-right-arrow{
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/mobile/il33-duality/greenArrow-mobile.svg);
    background-size: auto;
    height: 100%;
    width: 71px;
    background-repeat: no-repeat;
    margin-left: 68px;
    }
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-right-arrow .abs-text{
    font-size: 10px;
    color: #5F6D10;
    font-weight: 700;
    line-height: normal;
    min-width: 132px;
    font-family: "Barlow", sans-serif;
    margin-left: 25px;
    margin-top: 9px;
}

#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-right-arrow .abs-text p{
    font-family: "Barlow Semi Condensed", sans-serif;
        max-width: 90%;
}



#il33-duality #orange-accordion-content,
#il33-duality #green-accordion-content {
  position: relative;
  max-width: 325px;
  margin: 0 auto;
}

#il33-duality .cmp-accordion__panel {
  padding: 0;
}

#il33-duality .orange-borders.orange-background {
  background-color: #fdf6f2;
  margin: 40px auto 0;
  max-width: 110px;
  padding: 7px 10px;
}

#il33-duality .orange-borders {
  border: 1px solid #d34600;
  padding: 15px 13px 10px;
  margin: 22px 0 0;
  position: relative;
}

#il33-duality .orange-borders.receptor-container {
  margin: 18px 0 0;
}

#il33-duality .orange-borders:not(.orange-background) {
  background-color: #fffdfc;
}

#il33-duality .orange-title-content,
#il33-duality .green-borders.green-background .green-title-content {
  font-weight: 700;
  font-size: 14px;
  line-height: 100%;
  text-align: center;
  text-transform: uppercase;
}

#il33-duality .green-title-content {
  font-weight: 700;
  font-size: 12.29px;
  line-height: 100%;
  text-align: center;
  text-transform: uppercase;
}

#il33-duality .orange-title-content {
  color: #d34600;
}

#il33-duality .green-title-content {
  color: #5f6d10;
}

#il33-duality .item-title {
  font-weight: 700;
  font-size: 10px;
  line-height: 100%;
  text-align: center;
  color: #222222;
  margin: 10px 0 10px;
}

#il33-duality .item-text {
  font-weight: 500;
  font-size: 10px;
  line-height: 100%;
  text-align: center;
  color: #222222;
}

#il33-duality .flex-item-row,
#il33-duality .flex-item-column,
#il33-duality .orange-borders {
  display: flex;
  justify-content: center;
  align-items: center;
}

#il33-duality .flex-item-column,
#il33-duality .orange-borders {
  flex-direction: column;
}

#il33-duality .orange-text-content {
  font-weight: 400;
  font-size: 10px;
  line-height: 100%;
  text-align: center;
}

#il33-duality .full-arrow,
#il33-duality .small-arrow {
  position: relative;
}

#il33-duality .small-arrow .orange-title-content {
  margin-bottom: 10px;
}

#il33-duality .small-arrow img {
  width: 29.17px;
  height: 85px;
}

#il33-duality .full-arrow::after {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/orange-full-arrow-2.svg);
  background-size: contain;
  background-repeat: no-repeat;
  width: 118px;
  height: 104px;
  position: absolute;
  top: -43px;
  left: -50%;
  z-index: -1;
}

#il33-duality .small-arrow::after {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/orange-arrow-down-small.svg);
  background-size: contain;
  background-repeat: no-repeat;
  width: 13px;
  height: 25px;
  position: absolute;
  bottom: -25px;
  left: 50%;
}

#il33-duality .green-borders.green-background::after {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/green-arrow-full.svg);
  background-size: contain;
  background-repeat: no-repeat;
  width: 118px;
  height: 104px;
  position: absolute;
  top: -43px;
  right: -19.1%;
  z-index: -1;
}

#il33-duality #orange-accordion-content .flex-item-row {
  width: 100%;
  flex-direction: row;
  justify-content: space-between;
  align-items: flex-start;
  padding: 0 10px 0;
}

#il33-duality .flex-item-column p {
  margin: 7px 0 12px;
}

#il33-duality .flex-item-column .neutrophils-img {
  width: 32.94px;
}

#il33-duality .flex-item-column .macrophages-img {
  width: 34.65px;
}

#il33-duality .flex-item-column .endothelial-img {
  width: 33px;
}

#il33-duality .flex-item-column .eosinophils-img {
  width: 31.66px;
}

#il33-duality .flex-item-column .mast-img {
  width: 30.27px;
}

#il33-duality .flex-item-column .ILC2s-img {
  width: 30.54px;
}

#il33-duality .green-borders {
  background-color: #f7f8f3;
  border: 1px solid #737c0c;
}

#il33-duality .green-borders.green-background {
  margin: 40px auto 20px;
  max-width: max-content;
  padding: 7px 10px;
  position: relative;
}

#il33-duality .flex-item {
  display: flex;
  justify-content: center;
}

#il33-duality .flex-item-row {
  display: flex;
  flex-direction: column;
  justify-content: center;
  align-items: center;
}

#il33-duality .flex-item-row.epithelial-container,
#il33-duality .flex-item-row.formation-container {
  padding-bottom: 10px;
}

#il33-duality .second-item {
  padding: 25px 10px 10px;
}

#il33-duality .flex-item-row .green-title-content {
  padding-bottom: 10px;
  max-width: 80%;
}

#il33-duality .flex-item-row {
  padding-bottom: 25px;
}

#il33-duality .flex-item-row.clearance-container {
  padding-bottom: 20px;
}

#il33-duality .hypersecretion-container img,
#il33-duality .formation-container img {
  width: 44.57px;
}

#il33-duality .clearance-container img {
  width: 32.81px;
}

#il33-duality .epithelial-container img {
  width: 43.73px;
}


#il33-duality #txt-ed-bottom-note  {margin-top:8px}
#il33-duality .text-outside {
  font-weight: 400;
  font-size: 14px;
  line-height: 150%;
   padding-top: 20px; 
  color: #222222;
}
#il33-duality #dysregulation-notes .text-outside {
   padding-top: 12px; 
}
#il33-duality .right-arrow {
  position: relative;
  display: flex;
  justify-content: center;
  align-items: center;
  height: 100%;
}

#reduced-accordion-item-1547db9092-button {
  height: 100%;
}

#il33-duality .grey-link {
  font-family: "Barlow", sans-serif;
  font-weight: 600;
  font-size: 10px;
  line-height: 100%;
  text-align: center;
  color: #222222;
  padding-bottom: 10px;
}

#il33-duality .right-arrow::after {
}

#il33-duality #reduced-accordion .cmp-accordion__button:has(.right-arrow) {
  padding-bottom: 0;
  padding-top: 12px;
  height: 100%;
}

#il33-duality #reduced-accordion .cmp-accordion__title {
  height: 100%;
}

#il33-duality .right-arrow img {
  display: none;
}

#il33-duality
  #more-information-container
  #right-item-information
  #video-underline
  a {
  text-decoration: none;
}
#il33-duality
  #more-information-container
  #right-item-information
  #video-underline
  a
  span {
  text-decoration: underline;
}
#il33-duality
  #more-information-container
  #right-item-information
  #video-underline
  a
  span:hover {
  text-decoration: none;
}
#il33-duality #more-information-container .cmp-video .cmp-video__player{padding:0px;border-radius: 10px;}





#il33-duality #more-information-container .cmp-video .cmp-video__holder .cmp-video__content{display:none;}
#il33-duality #more-information-container {
  padding: 34px 15px 0;
}

#il33-duality #more-information-container h2 {
  font-weight: 700;
  font-size: 28px;
  line-height: 150%;
  text-transform: uppercase;
  color: #79266a;
  margin-bottom:0px;
}

#il33-duality #more-information-container .no-font-weight {
  font-weight: 400;
}
#il33-duality #more-information-container #right-item-information .youtubevideo{
  display:none;
}
#il33-duality #more-information-container #right-item-information .video .cmp-video.dyamic-embed .cmp-video__content{
  display:none;
}
#il33-duality #more-information-container #right-item-information .video .cmp-video.dyamic-embed .cmp-video__player{
  padding:0;
      max-width: 360px;
    margin: 0 auto;
}
#il33-duality #more-information-container #right-item-information .video .cmp-video.dyamic-embed .cmp-video__thumbnail {
  border-radius: 10px;
}
#il33-duality #more-information-container #right-item-information .video .cmp-video.dyamic-embed .cmp-video__video{
  height:203px;
}
#il33-duality .cmp-youtubevideo__player {
  padding: 0;
  max-width: 360px;
  margin: 0 auto;
}

#il33-duality .cmp-youtubevideo__thumbnail {
  border-radius: 10px;
}

#il33-duality .cmp-youtubevideo__content {
  padding-top: 10px;
}

#il33-duality #video-underline .text-video {
  margin: 14px 0 30px 0 ;
  font-size:18px;    
  line-height: normal;
}

#il33-duality .text-video {
  margin: 30px 0;
  font-weight: 400;
  font-size: 20px;
  line-height: 150%;
  color: #222222;
  text-align: center;
}

#il33-duality #text-play{
  display:flex;
  justify-content:center;
  align-items:center;
  gap:20px;
  padding:20px 16px 20px 24px;
  border:1px solid #79266A;
  margin-top: 30px;
  border-radius: 12px;
}

#il33-duality #text-play #play-button{
  width:48px;
}


#il33-duality #text-play .text-video.below-video{
    margin:0;
    text-align:left;
    font-size: 18px;
}

#il33-duality .youtubevideo{
  display:none;
}


#il33-duality .text-video a {
  font-weight: 700;
  text-decoration: underline;
  color: #46163f;
}
#il33-duality .text-video a:hover {
  text-decoration: none;
}
#il33-duality .purple-link img {
  position: relative;
  bottom: -2px;
  left: 5px;
}

#il33-duality #video-accordion {
  border-radius: 5px;
  padding: 0;
  border: 2px solid #f1e7ef;
  margin: 30px 0;
  position: relative;
}

#il33-duality
  #video-accordion:has(.cmp-accordion__panel.cmp-accordion__panel--expanded) {
  padding-bottom: 55px;
}

#il33-duality #video-accordion .cmp-accordion__button {
  padding: 15px 26px 15px 26px;
  flex-direction: row-reverse;
}
#il33-duality
  #video-accordion
  .cmp-accordion__button.cmp-accordion__button--expanded {
  padding-bottom: 0;
}
#il33-duality #video-accordion .cmp-accordion__panel--expanded {
  padding: 0 26px;
}
#il33-duality #video-accordion .cmp-accordion__title {
  font-family: "Barlow", sans-serif;
  font-weight: 600;
  font-size: 16px;
  line-height: 150%;
  padding-left: 20px;
  color: #333333;
}

#il33-duality #video-accordion .cmp-accordion__icon::before {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/close.svg);
  background-repeat: no-repeat;
  background-size: contain;
  position: absolute;
  left: 0;
  top: -6px;
  width: 11px;
  height: 20px;
}

#il33-duality
  #video-accordion
  .cmp-accordion__button--expanded
  .cmp-accordion__icon::before {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/open.svg);
  background-repeat: no-repeat;
  background-size: contain;
  position: absolute;
  left: 0;
  top: -1px;
  width: 12px;
  height: 10px;
}

#il33-duality #transcript-container p {
  font-weight: 400;
  font-size: 16px;
  line-height: 150%;
  padding-top: 10px;
  color: #222222;
}

#il33-duality .toggle-accordion {
  position: absolute;
  color: #46163f;
  font-weight: 700;
  font-size: 16px;
  line-height: 150%;
  bottom: 15px;
  left: 33%;
}

.collapse-all.active {
  text-decoration: underline;
}

.toggle-accordion .collapse-all,
.toggle-accordion .expand-all {
  font-family: "Barlow", sans-serif;
}

#il33-duality sup {
  font-weight: 400 !important;
  font-size: 60%;
  line-height: 0;
  font-style: normal;
  position: relative;
  top: 0;
}

#il33-duality .desktop-only,
#il33-duality #desktop-only {
  display: none;
}

#il33-duality .mobile-only,
#il33-duality #mobile-only {
  display: block;
}

#il33-duality .nowrap {
  white-space: nowrap;
}

#global-buttons .button-left,
#global-buttons .button-right,
#global-buttons #image-and-text-container {
  display: flex;
  flex-direction: row;
  flex-wrap: wrap;
}

#global-buttons .left-button-container,
#global-buttons .right-button-container {
  border: 1px solid #b4bd46;
  background-color: #f2fcd1;
  border-radius: 10px;
}
#global-buttons .left-button-container:hover,
#global-buttons .right-button-container:hover {
  border: 1.5px solid #f2fcd1;
  background: #e7ef7e;
  text-decoration: underline;
}
#il33-duality #body-wrapper a.left-button-targeting:hover {
  border: 1.5px solid #46163f;
  background: #46163f;
  text-decoration: underline;
}
#il33-duality #body-wrapper a.right-button-targeting:hover {
  border: 1.5px solid #46163f;
  background: #46163f;
  color: #ffffff;
  text-decoration: underline;
}
#il33-duality #body-wrapper a.right-button-targeting:hover img.exit-icon,
#il33-duality #body-wrapper a.right-button-targeting img.hover-exit-icon {
  display: none;
}
#il33-duality #body-wrapper a.right-button-targeting:hover img.hover-exit-icon {
  display: block;
}
#global-buttons #image-and-text-container {
  padding: 12px 0;
  flex: 0 0 90%;
  align-items: center;
}

#global-buttons .button-text {
  font-family: "Barlow", sans-serif;
  font-weight: 700;
  font-size: 20px;
  line-height: 150%;
  padding-right: 2px;
  color: #222222;
}

#global-buttons .icon-container {
  display: flex;
  justify-content: center;
  align-items: center;
  height: auto;
  flex: 0 0 10%;
}

#global-buttons .icon-container img {
  width: 18px;
}

#global-buttons #image-and-text-container img {
  flex: 0 0 13%;
  margin: 0 14px 0 18px;
  max-width: 54px;
}

#global-buttons #image-and-text-container p {
  flex: 0 0 70%;
}

#global-footnotes {
  padding: 0 15px 60px;
}

#global-section #gradient-background {
  background: linear-gradient(180deg, #fafafa 0%, #cdc8cd 100%);
}

#global-section #grey-background {
  background: #cdc8cd;
}

#global-section a {
  text-decoration: none;
  color: inherit;
}

#global-section a:hover {
  text-decoration: none;
  color: inherit;
}

#global-section #global-buttons {
  display: flex;
  flex-direction: column;
  gap: 20px;
  padding: 50px 15px 50px;
}

#global-targeting .title-targeting {
  font-family: "Barlow", sans-serif;
  font-weight: 700;
  font-size: 28px;
  line-height: 150%;
  text-align: center;
  text-transform: uppercase;
  color: #79266a;
}

#global-targeting .targeting-text {
  font-family: "Barlow", sans-serif;
  font-weight: 700;
  font-size: 20px;
  line-height: 150%;
  text-align: center;
  color: #222222;
}

#global-targeting .targeting-button-container {
  display: flex;
  justify-content: center;
  flex-direction: column;
  max-width: 360px;
  gap: 20px;
  margin: 30px auto 45px;
}

#global-targeting .left-button-targeting {
  background-color: #79266a;
  border: 1.5px solid #f1e7ef;
  color: #ffffff;
}

#global-targeting .right-button-targeting {
  background-color: #ffffff;
  border: 1.5px solid #79266a;
  color: #46163f;
}

#global-targeting .left-button-targeting,
#global-targeting .right-button-targeting {
  display: flex;
  justify-content: center;
  align-items: center;
  gap: 15px;
  border-radius: 5px;
  padding: 13.7px 25px;
}

#global-targeting .right-button-targeting {
  padding: 12.2px 25px;
}

#global-targeting .targeting-button-container p {
  font-family: "Barlow", sans-serif;
  font-weight: 700;
  font-size: 18px;
  line-height: 100%;
}

#global-targeting .left-button-targeting img {
  width: 21px;
}

#global-targeting .right-button-targeting img {
  width: 24px;
}

#global-footnotes .footnotes-text {
  font-family: "Barlow", sans-serif;
  font-weight: 400;
  font-size: 12px;
  line-height: 150%;
  color: #222222;
}

#global-footnotes .footnotes-text.text-two{
  padding-top:14px;
  text-indent:-5px;
  padding-bottom: 4px;
}

#global-accordion,
#global-section .accordion.panelcontainer {
  width: 100%;
}

#global-accordion {
  border-radius: 5px;
  padding: 0;
  border: 2px solid #9c919a;
  margin-top: 20px;
  position: relative;
}

#global-accordion .cmp-accordion__header {
  padding: 0;
}

#global-accordion .cmp-accordion__button {
  padding: 15px 10px 15px 25px;
  flex-direction: row-reverse;
}
#global-accordion .cmp-accordion__panel.cmp-accordion__panel--expanded {
  padding-bottom: 0;
}
#global-accordion .cmp-accordion__panel--expanded {
  display: block;
  padding: 0 10px 0 22px;
}
#global-accordion .cmp-accordion__title {
  font-family: "Barlow", sans-serif;
  font-weight: 700;
  font-size: 16px;
  line-height: 150%;
  color: #222222;
  padding-left: 6px;
}

#global-accordion .cmp-accordion__icon::before {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/close.svg);
  background-repeat: no-repeat;
  background-size: contain;
  position: absolute;
  left: -13px;
  top: -5px;
  width: 11px;
  height: 20px;
}

#global-accordion
  .cmp-accordion__button--expanded
  .cmp-accordion__icon::before {
  content: "";
  background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/open.svg);
  background-repeat: no-repeat;
  background-size: contain;
  position: absolute;
  left: -13px;
  top: -1px;
  width: 12px;
  height: 10px;
}

#global-accordion ol {
  list-style: none;
  padding-left: 2.2ch;
  padding-top: 0;
  margin: 0;
  counter-reset: item;
}
#global-accordion ol a{
  text-decoration:underline;
      color: #222222;
}
#global-accordion ol li::after {
  content: counter(item) ".";
  position: absolute;
  width: 2.5ch;
  text-align: right;
  left: -33px;
  top: 0;
  color: #79266a;
  font-size: 16px;
  font-weight: 600;
}

#global-accordion ol li {
  font-family: "Barlow", sans-serif;
  font-weight: 400;
  font-size: 16px;
  line-height: 150%;
  color: #222222;
  padding: 0 0 15px;
  counter-increment: item;
  position: relative;
}

#global-accordion ol li.special-padding {
  padding-right: 7px;
}

#global-buttons,
#global-targeting {
  padding: 0 15px;
}

#global-targeting .left-button-targeting:hover {
  text-decoration: none;
  color: #ffffff;
}

#il33-duality .cmp-youtubevideo__item-title {
  display: none;
}

#il33-duality #more-information-container .cmp-video .cmp-video__player .cmp-video__video:focus-visible{
  outline: 3px solid #1a73e8 !important;
  outline-offset: 2px !important;
}

#global-accordion ol li a[href^="tel"] {
  color: inherit;
  text-decoration: none;
  pointer-events: none; 
}



/* global CSS end */

@media only screen and (min-width: 992px) {
      #il33-duality #ed-container p.dysregulation-title {
    max-width: 100%;
}
    
    #il33-duality #more-information-container #right-item-information .video .cmp-video.dyamic-embed .cmp-video__player{
      max-width: 100%;
  height:100% !important;
}
   #il33-duality #more-information-container #right-item-information .video .cmp-video.dyamic-embed .cmp-video__video{
  height:355px;
} 

  #il33-duality #body-wrapper {
    margin: -45px 0 0;
    padding: 0;
  }

  #il33-duality #title-section,
  #il33-duality #reduced-il-section,
  #il33-duality #purple-container,
  #il33-duality #dysregulation-container,
  #il33-duality #ed-container{
    padding: 0;
    max-width: 1260px;
    margin: 0 auto;
  }

  #il33-duality #title-section {
    margin-top: 143px;
    padding: 61px 0 40px;
  }

  #il33-duality .eyebrown-text {
    font-size: 20px;
    line-height: 150%;
  }
  
#il33-duality #key-role-section .key-role-left{
  border-bottom:none;

}

  #il33-duality #key-role-section #flex-right img{
  padding-top:0px;
}

#il33-duality #key-role-section #responsive-flex #flex-left{
      border-right:1px solid #9C919A;
      padding-right:50px;
}

#il33-duality #key-role-section #responsive-flex #flex-left ul{
    padding-right:0;
}

  #il33-duality h1 {
    font-size: 48px;
    line-height: 100%;
    margin: -7px 0 0;
  }

  #il33-duality #title-section h2 {
    font-size: 20px;
  }

  #il33-duality #left-item {
    display: flex;
    justify-content: center;
    align-items: center;
  }

  #il33-duality #images-container img {
    width: 128px;
  }
  
  #il33-duality #reduced-il-section {
    display: flex;
    justify-content: center;
    flex-wrap: wrap;
    gap: 15px;
  }

  #il33-duality #left-item {
    flex-direction: column;
  }

  #il33-duality #reduced-il-section .container.responsivegrid:has(#left-item),
  #il33-duality #reduced-il-section .container.responsivegrid:has(#right-item) {
    flex: 0 0 38.8%;
  }

  #il33-duality
    #reduced-il-section
    .container.responsivegrid:has(#middle-item) {
    flex: 0 0 20%;
  }

  #il33-duality .flex-item-row .green-title-content  {
    max-width: 100%;
  }

  #il33-duality .arrow-box {
    padding: 22px 40px 22px 28px;
    background: linear-gradient(
      90deg,
      rgba(156, 145, 154, 0) 0%,
      rgba(205, 200, 205, 0.15) 25.96%,
      #cdc8cd 100%
    );
    clip-path: polygon(
      0 0,
      calc(100% - 40px) 0,
      100% 50%,
      calc(100% - 40px) 100%,
      0 100%
    );
    max-width: 246px;
    width: 100%;
    height: 104px;
    display: flex;
    justify-content: center;
    align-items: center;
  }

  #il33-duality #reduced-il-section h2 {
    font-size: 40px;
  }

  #il33-duality #middle-item {
    margin-top: 40px;
    margin-bottom: 0;
    display: block;
  }

  #il33-duality #right-item {
    padding-left: 7px;
  }

  #il33-duality #body-wrapper ul {
    padding-right: 16px;
  }

  #il33-duality #body-wrapper ul li {
    font-size: 20px;
    padding: 0 0 4px 15px;
  }

  #il33-duality #images-container {
    margin-bottom: 17px;
  }

  #il33-duality #purple-container {
    max-width: 1152px;
    margin: 30px auto 66px;
    padding: 29px 0;
  }

  #il33-duality #purple-container h2 {
    font-size: 24px;
  }

  #il33-duality #purple-container::after {
    left: 49.1%;
  }

  #il33-duality #dysregulation-container {
    padding: 40px 60px;
  }
  #il33-duality #dysregulation-container #first-organ{ margin: 0 68px;}
  #il33-duality #dysregulation-container h2 {
    font-size: 32px;
    max-width: 932px;
    margin: 0 auto;
  }

#dysregulation-container #first-arrow {
        max-width: 68px;
        margin-top: 10px;
        margin-bottom: 12px;
        padding-left: 25px;
}
#dysregulation-container #waste {
        max-width: 150px;
        margin: 0 auto;
        margin-bottom: 10px;
        padding-left: 18px;
        padding-right: 0;
    }
#dysregulation-container .first-time.inbtw-text .text-1{        font-size: 24px; padding-left: 17px;}
#dysregulation-container .first-time.inbtw-text .text-2{font-size: 24px; padding-left: 17px;padding-bottom:19px}
#il33-duality #downstream-cell-types, #il33-duality #inflammation-cell-types{    gap:0px}
#il33-duality #inflammation-cell-types{    gap:193px}
#il33-duality #downstream-cell-types{
            JUSTIFY-CONTENT: LEFT;
        MARGIN-LEFT: 235PX;
}
#il33-duality #downstream-cell-types .cmp-imagelist,#il33-duality #inflammation-cell-types .cmp-imagelist{
    flex-direction: row;gap:0px;padding-right: 0px;
}
#il33-duality #downstream-cell-types .imagelist:first-child .cmp-imagelist{
    padding-right: 44px;
}
#il33-duality #downstream-cell-types .imagelist:last-child .cmp-imagelist{
    padding-left: 37px;
}
 #il33-duality #inflammation-cell-types .cmp-imagelist{
}
#il33-duality #downstream-cell-types .imagelist {
    margin-top: 37px;
}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item, #il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item{
    gap:12px;
}

#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item .cmp-imagelist__description,
 #il33-duality #inflammation-cell-types  .cmp-imagelist .cmp-imagelist__item .cmp-imagelist__description{display:none;}

#il33-duality #downstream-cell-types .imagelist:first-child .cmp-imagelist li:nth-child(2){margin-left: 32px;        margin-right: 30px;}
#il33-duality #downstream-cell-types .imagelist:last-child .cmp-imagelist li:nth-child(2){ margin-left: 20px;        margin-right: 33px;gap:8px;}
#il33-duality #downstream-cell-types .imagelist:last-child .cmp-imagelist li:nth-child(3){
  gap: 7px;
}
#il33-duality #downstream-cell-types .imagelist:last-child .cmp-imagelist li:first-child{
  gap: 14px;
}
#il33-duality #inflammation-cell-types #inflammation-cell-types-cont1 .imagelist .cmp-imagelist li:nth-child(2){margin-left: 57px;        margin-right: 67px;gap: 8px;}
#il33-duality #inflammation-cell-types #inflammation-cell-types-cont2 .imagelist .cmp-imagelist li:nth-child(2){ margin-left: 41px;}
#il33-duality #inflammation-cell-types #inflammation-cell-types-cont1 .imagelist .cmp-imagelist li:first-child{
  gap: 17px;
}
  #il33-duality #inflammation-cell-types #inflammation-cell-types-cont1 .imagelist .cmp-imagelist li:nth-child(3){
  gap: 14px;
  margin-top: 0;
}
#il33-duality #inflammation-cell-types #inflammation-cell-types-cont2 .imagelist .cmp-imagelist li{
  gap:4px;
}



#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.mast-cells img{ width:47px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.ILC2s img{ width:49px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Eosinophils img{width:48px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Neutrophils img{width:48px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Macrophages img{width:67px;}
#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item.Tcells img{width:56px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-4 img{width:48px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-5 img{width:30px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-13 img{width:39px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IFN-y img{width:50px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.TNF-a img{width:51px;}
#il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item.IL-13 {margin-top:5px}

#il33-duality #downstream-cell-types .cmp-imagelist .cmp-imagelist__item p, #il33-duality #inflammation-cell-types .cmp-imagelist .cmp-imagelist__item p{font-size:20px;}

#dysregulation-container .inbtw-text.second-time {
    padding: 17px 0 19px 25px;
    font-size: 25px;
}
#inflammation-cell-types .right-list-txt, #inflammation-cell-types .left-list-txt{
    font-size:24px;
}

#il33-duality #dysregulation-notes .text-outside{padding-top:30px;margin: 0px; max-width: 100%;}

#il33-duality #key-role-section{        
    max-width: 1260px;
    margin: 0 auto;
    padding: 40px 60px;
}
#il33-duality #key-role-section #responsive-flex #flex-left, #il33-duality #key-role-section #responsive-flex #flex-right,
#il33-duality #key-role-section #responsive-flex {
    flex-direction: row;
}
#il33-duality #key-role-section #responsive-flex{
    /* gap:50px; */
    justify-content:center;
}
#il33-duality #key-role-section #responsive-flex .container{
    width: 560px;
}

  #il33-duality #key-role-section #responsive-flex #flex-right{
    padding-left:50px;
  }
#il33-duality #key-role-section #responsive-flex .image{width:120px;}
#il33-duality #key-role-section #responsive-flex .text{width:370px;}

#il33-duality #key-role-section #responsive-flex .text  ul li{font-size:18px;}
#il33-duality #key-role-section .key-role-left{padding-bottom:0px}

#il33-duality #h2bioactive{margin-top:50px}
#il33-duality #h2bioactive h2{        
    margin: 0 auto 30px;
        max-width: 1260px;
        font-size: 40px;
        line-height: 100%;
}

#il33-duality #ed-container{padding:40px 60px;}
#il33-duality #ed-container #txt-ed-title{ padding-bottom:40px;}

  #il33-duality #airway-epithelial-damage-image {
    max-width: 100%;        padding: 0 60px;
  }
  #il33-duality #colourArrows,
  #il33-duality #duality-section,
  #il33-duality #txt-ed-bottom-line.cmp-text{    padding: 0 60px;}

#il33-duality #ed-container .mod-dl{text-align:center;margin-top:40px}
#il33-duality #ed-container #colourArrows #txt-arrow-container{
    width: 100%;
}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container{height:142px;display: flex;width: 100%;}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-left-arrow{
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/redArrow-desktop.svg);
    background-size: auto;
    height: 100%;
    width: 245px;
    background-repeat: no-repeat;
    left: 0;
    margin-left: 182px;
}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-right-arrow{
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/greenArrow-desktop.svg);
    background-size: auto;
    height: 100%;
    width: 245px;
    background-repeat: no-repeat;
    margin-left: 146px;
}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-right-arrow .abs-text{
    font-size: 20px;
    min-width: 400px;
    margin-left: 62px;
    margin-top: 22px;
}
#il33-duality #ed-container #colourArrows #txt-arrow-container .arrow-container .path-right-arrow .abs-text p{
    display:inline;
}
#il33-duality #duality-section #duality-box1,
#il33-duality #duality-section #duality-box-2 {
    width: 427px;
    flex-direction: row;
}
#il33-duality #duality-section #duality-box1{
    padding: 29px 18px 13px 19px;
    gap:18px;
    border-width: 2px;
    border-radius: 20px;
    background:#fff;
    align-items: flex-start;
}
#il33-duality #duality-section #duality-box-2{
    padding: 17px 33px 22px 23px;
    gap:12px;
    border-width: 2px;
    border-radius: 20px;
    background:#fff;
    align-items: flex-start;
}
#il33-duality #duality-section #red-shadow, #il33-duality #duality-section #green-shadow{
    max-width: 427px;                display: flex;
}
#il33-duality #duality-section .inside-box.red .text-1{padding:0px}
#il33-duality #duality-section #duality-box1 .image,
#il33-duality #duality-section #duality-box-2 .image {
    width: 86px;margin-top:13px;
}
#il33-duality #duality-section #duality-box1 #duality-box1-txt-cont,
#il33-duality #duality-section #duality-box-2 #duality-box-2-txt-cont{
    width: 285px;
}
#il33-duality #duality-section .inside-box .text-1{font-size:24px;text-align:left;}
#il33-duality #duality-section .inside-box .text-2{font-size:20px;text-align:left;    padding: 0 3px 0 0;}
#il33-duality #duality-section #red-shadow #txt-red-shadow .shade-text, 
#il33-duality #duality-section #green-shadow #txt-green-shadow .shade-text{
    font-size:20px;text-align:left;padding:0px;
}
      #il33-duality #duality-section #red-shadow #txt-red-shadow .shade-text,
      #il33-duality #duality-section #green-shadow #txt-green-shadow .shade-text{
        line-height:normal;
      }
#il33-duality #duality-section .inside-box.green .text-1 {
    padding: 0px 5px 0 0;
}
#il33-duality #duality-section #red-shadow .image {    width: 67px;margin-top: 0px;        margin-left: 10px;        margin-right: 0;}
#il33-duality #duality-section #red-shadow{
            gap: 25px;
    padding-top: 40px;
        padding-right: 30px;
        padding-left: 20px;
        margin-top:-20px;
    }
#il33-duality #duality-section #red-shadow #txt-red-shadow {width:267px;        margin-top: 0px;}

#il33-duality #duality-section #green-shadow .image {    width: 67px;margin-top: 0px;margin-left: 0px;        margin-right: 0;}
#il33-duality #duality-section #green-shadow{
           gap: 22px;
    padding-top: 40px;
        padding-right: 30px;
        padding-left: 18px;
        margin-top:-20px;
    }
#il33-duality #duality-section #green-shadow #txt-green-shadow {width:275px;        margin-top: 3px;}

#il33-duality #duality-section #grey-container {
    width: 137px;
    margin-left: 12px;
    margin-top: 57px;
}
#il33-duality #txt-ed-bottom-note{margin-top:40px;}
#il33-duality #txt-ed-bottom-note .text-outside{margin:0px;padding:0px;max-width: 100%;}
#il33-duality #txt-associate{margin:0px;} 
#il33-duality #txt-associate .two-fold-text{font-size:40px;
    padding-top: 40px;
        padding-bottom: 70px;
        padding-left: 25px;
        padding-right: 25px;
        max-width: 1050px;
        margin: auto;
        border-bottom:0px;
}
#il33-duality #more-information-container{border-top:1px solid #9C919A;
    align-items: center;
    margin: 0 auto;
    max-width: 1260px;
    padding: 70px 0 0;
  }
  #il33-duality #video-underline .text-video{font-size:24px;}
#il33-duality #more-information-container #left-item-information .video #cmp_video{max-width:893px;        margin: auto;}
#il33-duality #more-information-container  #text-play{     max-width: 614px;
    margin: auto;margin-top: 30px;
}


















#il33-duality #downstream-cell-types .image #middle-arrow1 {
    height: 171px;
}
#il33-duality .dysregulation-text {
    font-size: 24px;
    margin: 21px 0 29px;
}
  #il33-duality .dysregulation-image-title {
    font-size: 20px;
  }


  #il33-duality .tooltip::before {
    left: 71.2%;
    width: 17px;
    height: 17px;
    top: -9px;
  }
  #il33-duality .tooltip {
    bottom: -61px;
    left: 49%;
    width: 310px;
    padding: 12px;
    border-radius: 10px;
  }

  #il33-duality .tooltip-content {
    font-size: 14px;
    line-height: 100%;
    padding-right: 5px;
    display: inline-block;
  }

  #il33-duality .right-arrow .tooltip-close img {
    width: 16px;
    height: 16px;
    display: block;
    bottom: 0;
  }

  #il33-duality #reduced-accordion .flex-items {
    flex-direction: row;
  }

  #il33-duality #reduced-accordion .cmp-accordion__header {
    flex: 0 0 380px;
    width: 380px;
  }

  #il33-duality #reduced-accordion .accordion-subtitle {
    font-size: 18px;
    line-height: 20px;
    padding: 3px 5px 0;
  }

  #il33-duality #reduced-accordion .accordion-title {
    font-weight: 700;
    font-size: 25.89px;
    line-height: normal;
  }

  #il33-duality #reduced-accordion .flex-items img {
    width: 30px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__button {
    padding: 15px 30px 34px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__button:has(.right-arrow) {
    padding: 12px 5px 0;
    height: 125px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__icon::before {
    width: 40px;
    height: 40px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__icon {
    left: 43%;
    bottom: 20px;
  }

  #il33-duality #reduced-accordion .flex-items {
    gap: 18px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__header:has(.right-arrow) {
    flex: 0 0 222px;
    width: 222px;
  }

  #il33-duality .right-arrow::after {
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/arrow-with-icons-desktop.svg);
    width: 219px;
    height: 39px;
    background-size: cover;
    top: 9px;
    left: -3px;
  }

  #il33-duality .grey-link {
    font-size: 20px;
    line-height: 150%;
    padding: 0 15px;
  }

  #il33-duality .cmp-accordion__title {
    height: 100%;
  }

  #il33-duality
    #reduced-accordion
    #reduced-accordion-item-1547db9092-button
    .cmp-accordion__icon::before {
    content: none;
  }

  #il33-duality .right-arrow {
    align-items: end;
  }

  #il33-duality .right-arrow img {
    width: 14px;
    bottom: -4px;
  }

  #il33-duality .text-outside {
    font-size: 14px;
    line-height: 150%;
    max-width: 983px;
    margin: 14px auto 0;
  }

  #il33-duality #reduced-accordion {
    justify-content: center;
    margin-top: -2px;
  }

  #il33-duality
    #reduced-accordion
    .cmp-accordion__item:has(#orange-accordion-content),
  #il33-duality
    #reduced-accordion
    .cmp-accordion__item:has(#green-accordion-content) {
    flex: 0 0 380px;
    width: 380px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__item {
    display: block;
  }

  #il33-duality .full-arrow::after {
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/arrow-down-big.svg);
    width: 24px;
    height: 117px;
    top: -43px;
    left: 35%;
  }

  #il33-duality .small-arrow::after {
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/arrow-down-small.svg);
    width: 24px;
    height: 45px;
    bottom: -46px;
    left: 45%;
  }

  #il33-duality .green-borders.green-background::after {
    background-image: url(/content/dam/intelligentcontent/unbranded/dualcopdburden-microsite/us/en/images/desktop/il33-duality/green-arrow-down-big.svg);
    width: 24px;
    height: 117px;
    top: -50px;
    left: 39.8%;
  }

  #il33-duality .orange-borders.orange-background {
    padding: 10px 5px;
    max-width: 125px;
    margin: 38px auto 0;
  }

  #il33-duality .orange-title-content,
  #il33-duality .green-borders.green-background .green-title-content,
  #il33-duality .green-title-content {
    font-size: 16px;
  }

  #il33-duality .orange-borders.receptor-container {
    margin: 37px 0 0;
  }

  #il33-duality .orange-borders {
    margin: 43px 0 0;
  }

  #il33-duality .small-arrow img {
    width: 33px;
    height: 96.16px;
    margin-right: 14px;
  }

  #il33-duality .small-arrow .orange-title-content {
    margin-bottom: 5px;
  }

  #il33-duality .item-title {
    font-size: 14px;
    margin: 19px 0 10px;
  }

  #il33-duality .item-text {
    font-size: 12px;
  }

  #il33-duality .flex-item-column .neutrophils-img {
    width: 41.17px;
  }

  #il33-duality .flex-item-column .macrophages-img {
    width: 40.29px;
  }

  #il33-duality .flex-item-column .endothelial-img {
    width: 41.25px;
  }

  #il33-duality .flex-item-column .eosinophils-img {
    width: 39.58px;
  }

  #il33-duality .flex-item-column .mast-img {
    width: 37.84px;
  }

  #il33-duality .flex-item-column .ILC2s-img {
    width: 38.17px;
  }

  #il33-duality .orange-text-content {
    font-size: 12px;
  }

  #il33-duality .text-outside {
    margin: 22px auto 0;
  }

  #il33-duality .green-borders.green-background {
    margin: 40px auto 37px;
  }

  #il33-duality .hypersecretion-container img,
  #il33-duality .formation-container img {
    width: 58px;
  }

  #il33-duality .clearance-container img {
    width: 42.7px;
  }

  #il33-duality .epithelial-container img {
    width: 56.91px;
  }

  #il33-duality .second-item {
    padding: 25px 10px 13px;
  }

  #il33-duality #orange-accordion-content,
  #il33-duality #green-accordion-content {
    max-width: 100%;
  }

  #il33-duality #orange-accordion-content .flex-item-row {
    padding: 0;
  }

  #il33-duality
    #more-information-container
    #left-item-information
    #video-underline
    a {
    text-decoration: none;
  }
  #il33-duality
    #more-information-container
    #left-item-information
    #video-underline
    a
    span {
    text-decoration: underline;
  }
  #il33-duality
    #more-information-container
    #left-item-information
    #video-underline
    a
    span:hover {
    text-decoration: none;
  }
  #il33-duality .toggle-accordion {
    left: 45.2%;
  }



  #il33-duality .container.responsivegrid:has(#video-accordion) {
    flex: 0 0 100%;
  }

  #il33-duality .cmp-youtubevideo__video,
  #il33-duality .cmp-youtubevideo__player {
    height: auto !important;
  }

  #il33-duality .text-video {
    /* max-width: 567px; */
    margin: 0 auto;
    font-size: 24px;
    margin-top: 25px;
    margin-bottom: 30px;
  }

  #il33-duality #more-information-container h2 {
    font-size: 48px;
  }

  #il33-duality #video-accordion,
  #il33-duality .accordion.panelcontainer {
    width: 100%;
  }

  #il33-duality #video-accordion {
    margin: 30px 0 60px;
  }

  #il33-duality .cmp-youtubevideo__player {
    max-width: 100%;
  }

  #il33-duality #left-item-information {
    /* display: flex; */
    flex-direction: column;
  }

  #il33-duality #video-accordion .cmp-accordion__icon::before {
    width: 13px;
    top: -5.5px;
  }

  #il33-duality sup {
    line-height: 100%;
    font-size: 60%;
  }

  #il33-duality .desktop-only,
  #il33-duality #desktop-only {
    display: block;
  }

  #il33-duality .mobile-only,
  #il33-duality #mobile-only {
    display: none;
  }

  #global-section #global-buttons {
    display: flex;
    flex-direction: row;
    gap: 30px;
    padding: 60px 0 40px;
  }

  #global-buttons .button-text {
    font-size: 24px;
  }

  #global-buttons #image-and-text-container img {
    max-width: 75px;
    margin: 0 14px 0 28px;
  }

  #global-buttons .icon-container img {
    width: 19.89px;
  }

  #global-buttons #image-and-text-container {
    padding: 30px 0;
  }

  #global-buttons #image-and-text-container p {
    flex: 0 0 75%;
  }

  #global-targeting .targeting-button-container {
    flex-direction: row;
    max-width: 100%;
    gap: 50px;
  }

  #global-buttons,
  #global-footnotes {
    max-width: 1280px;
    margin: 0 auto;
  }

  #global-targeting {
    max-width: 1090px;
    margin: 0 auto;
    padding: 0 0 7px;
  }

  #global-targeting .title-targeting {
    font-size: 40px;
  }

  #global-targeting .targeting-text {
    font-size: 24px;
    margin-top: 5px;
    margin-bottom: 40px;
  }

  #global-targeting .targeting-button-container p {
    font-size: 20px;
  }

  #global-targeting .left-button-targeting,
  #global-targeting .right-button-targeting {
    width: 100%;
    padding: 16.2px 25px;
    max-width: 499px;
  }

  #global-targeting .left-button-targeting img,
  #global-targeting .right-button-targeting img {
    width: 24px;
  }

  #global-footnotes .footnotes-text {
    font-size: 14px;
  }

  #global-accordion .cmp-accordion__title {
    width: 100%;
    padding-left: 7px;
  }

  #global-accordion .cmp-accordion__icon::before {
    width: 13px;
    top: -5px;
    left: -14px;
  }

  #global-accordion
    .cmp-accordion__button--expanded
    .cmp-accordion__icon::before {
    top: 0;
    left: -13px;
  }

  #global-footnotes {
    padding: 0 0 60px;
  }

  #global-accordion {
    padding: 0;
  }
  #global-accordion .cmp-accordion__button {
    padding: 13px 10px 13px 29px;
  }
  #global-accordion .cmp-accordion__panel--expanded {
    padding: 0 10px 0 27px;
  }
  #global-accordion .cmp-accordion__header {
    padding: 0;
  }

  #global-buttons .left-button-container,
  #global-buttons .right-button-container {
    width: 100%;
    max-width: 614px;
  }

  #global-buttons .button-left,
  #global-buttons .button-right {
    display: flex;
    width: 100%;
    max-width: 614px;
  }

  /* global CSS end */
}

@media screen and (min-width: 410px) and (max-width: 992px) {
  #il33-duality #images-container .image {
    display: flex;
    justify-content: center;
  }
}

@media screen and (min-width: 992px) and (max-width: 1300px) {
  #il33-duality #reduced-il-section {
    padding: 0 15px;
  }

  #il33-duality #more-information-container {
    padding: 40px 15px;
  }

  #il33-duality #title-section {
    padding: 40px 15px 58px;
  }

  #il33-duality #reduced-il-section .container.responsivegrid:has(#left-item),
  #il33-duality #reduced-il-section .container.responsivegrid:has(#right-item) {
    flex: 0 0 37.8%;
  }

  #il33-duality #body-wrapper > div:nth-child(3) {
    padding: 0 15px;
  }

  #il33-duality #dysregulation-container {
    margin: 0 15px;
  }

  #il33-duality
    #reduced-accordion
    .cmp-accordion__item:has(#orange-accordion-content),
  #il33-duality
    #reduced-accordion
    .cmp-accordion__item:has(#green-accordion-content) {
    flex: 0 0 30%;
    width: 30%;
  }

  #il33-duality #reduced-accordion .cmp-accordion__item:has(.right-arrow) {
    flex: 0 0 30%;
    width: 30%;
  }

  #il33-duality #reduced-accordion .cmp-accordion__header {
    flex: 0 0 100%;
    width: 100%;
  }

  #il33-duality #reduced-accordion .cmp-accordion__header:has(.right-arrow) {
    width: 100%;
  }

  #il33-duality .right-arrow::after {
    width: 100%;
  }

  #il33-duality .full-arrow::after {
    left: 41%;
  }

  #il33-duality .green-borders.green-background::after {
    left: 43.8%;
  }

  #il33-duality .tooltip {
    left: 79%;
  }

  #il33-duality .grey-link {
    max-width: 240px;
    margin: 0 auto;
  }

  /* global section start */

  #global-targeting {
    padding: 0 15px;
  }

  #global-section #global-buttons {
    padding: 60px 15px 40px;
  }

  #global-buttons #image-and-text-container p {
    flex: 0 0 70%;
  }

  #global-footnotes {
    padding: 0 15px 60px;
  }

  #global-buttons .button-text {
    font-size: clamp(1.25rem, 0.6982rem + 0.8909vw, 1.5rem);
  }

  /* global section end */
}

@media screen and (max-width: 389px) {
  #il33-duality .arrow-box {
    width: 100%;
  }

  #il33-duality #reduced-accordion .cmp-accordion__header {
    flex: 0 0 83px;
    width: 83px;
  }

  #il33-duality #reduced-accordion .cmp-accordion__header:has(.right-arrow) {
    flex: 0 0 87px;
    width: 87px;
  }

  #il33-duality #reduced-accordion .accordion-title {
    font-size: 12px;
    text-align: center;
  }

  #il33-duality .tooltip {
    left: 94%;
  }

  #il33-duality .full-arrow::after {
    width: 94px;
    top: -29px;
    left: -27%;
  }

  #il33-duality .small-arrow::after {
    left: 51%;
    width: 11px;
  }

  #il33-duality .green-borders.green-background::after {
    top: -36px;
    right: -8.1%;
    width: 107px;
  }

  #il33-duality .text-video {
    font-size: 18px;
  }

  #global-buttons #image-and-text-container {
    flex: 0 0 85%;
  }

  #global-buttons #image-and-text-container p {
    flex: 0 0 60%;
  }

  #global-buttons .button-text {
    font-size: 16px;
  }

}